Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria

The misuse of antibiotics combined with a lack newly developed ones is the main contributors to current antibiotic resistance crisis. There dire need for new and alternative antibacterial options nanotechnology could be solution. Metal-based nanoparticles, particularly silver nanoparticles (NAg), have garnered widespread popularity due their unique physicochemical properties broad-spectrum activity. Consequently, NAg has seen extensive incorporation in many types products across healthcare consumer market. Despite clear evidence strong efficacy NAg, studies raised concerns over development silver-resistant bacteria. Resistance cationic (Ag + ) been recognised years, but it recently found that bacterial also possible. It understood exposure bacteria toxic heavy metals like can induce emergence through process co-selection. Acinetobacter baumannii Gram-negative coccobacillus opportunistic nosocomial pathogen. was listed as “number one” critical level priority pathogen because significant rise this species. proven bactericidal activity towards A. , even against strains display multi-drug resistance. However, despite ample metal (including silver; Ag bacterium, reports metal-driven co-selection resistance, little research dedicated assessing potential . This worrisome, increasingly indiscriminate use promote species, what occurred antibiotics.